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10.1016/j.ccell.2016.03.009 http://scihub22266oqcxt.onion/10.1016/j.ccell.2016.03.009 C4852161!4852161 !27070699     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27070699 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell 2016 ; 29 (4 ): 440-451 Nephropedia Template TP {{tp|p=27070699 |t=2016. Intratumoral Heterogeneity of the Epigenome |pdf=|usr=}}{{27070699 }} gab.com Text Intratumoral Heterogeneity of the Epigenome JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27070699 #FOAvip Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may drive drug resistance, and the degree of epigenetic ITH at diagnosis may predict patient outcome. This perspective presents these current concepts and clinical implications of epigenetic ITH, and the experimental and computational techniques at the forefront of ITH exploration. Twit Text FOAVip Intratumoral Heterogeneity of the Epigenome ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=27070699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27070699 #FOAvip English Wikipedia <ref>{{Cite pmid|27070699 }}</ref> Intratumoral Heterogeneity of the Epigenome #MMPMID27070699 Mazor T ; Pankov A ; Song JS ; Costello JF Cancer Cell 2016[Apr]; 29 (4 ): 440-451 PMID27070699 show ga Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may drive drug resistance, and the degree of epigenetic ITH at diagnosis may predict patient outcome. This perspective presents these current concepts and clinical implications of epigenetic ITH, and the experimental and computational techniques at the forefront of ITH exploration. |*Epigenesis, Genetic [MESH] |*Epigenomics [MESH] |*Gene Expression Regulation, Neoplastic [MESH] |*Genetic Heterogeneity [MESH] |Cell Transformation, Neoplastic/*genetics [MESH] |CpG Islands/genetics [MESH] |DNA Methylation [MESH] |DNA, Neoplasm/chemistry/genetics [MESH] |Disease Progression [MESH] |Forecasting [MESH] |Humans [MESH] |Mutation [MESH] |Neoplasms/*genetics/pathology [MESH] |Neoplastic Stem Cells/metabolism [MESH]Intratumoral Heterogeneity of the Epigenome (epmc).pdf DeepDyve Pubget Overpricing