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2008 ; 10
(11
): 2151-8
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Intracellular microbes and haemophagocytosis
#MMPMID18616693
Silva-Herzog E
; Detweiler CS
Cell Microbiol
2008[Nov]; 10
(11
): 2151-8
PMID18616693
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Haemophagocytosis (hemophagocytosis) is the phenomenon of activated macrophage
consumption of red and white blood cells, including professional phagocytes and
lymphocytes. It can occur in patients with severe cases of intracellular
microbial infection, including avian influenza, leishmaniasis, tuberculosis and
typhoid fever. While well-known to physicians since at least the mid-1800s,
haemophagocytosis has been little studied due to a paucity of tractable animal
and cell culture models. Recently, haemophagocytosis has been described in a
mouse model of typhoid fever, and it was noted that the infectious agent,
Salmonella enterica, resides within haemophagocytic macrophages in mice. In
addition, a cell culture model for haemophagocytosis revealed that S. enterica
preferentially replicate in haemophagocytic macrophages. This review describes
how, at the molecular and cellular levels, S. enterica may promote and take
advantage of haemophagocytosis to establish long-term systemic infections in
mammals. The role, relevance and possible molecular mechanisms of
haemophagocytosis are discussed within the context of other microbial infections
and of genetic deficiencies in which haemophagocytosis occurs and is associated
with morbidity.
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