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10.1113/JP272781

http://scihub22266oqcxt.onion/10.1113/JP272781
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C5430224!5430224 !28303572
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suck abstract from ncbi


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pmid28303572
      J+Physiol 2017 ; 595 (10 ): 3041-3051
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  • Intracellular calcium release channels: an update #MMPMID28303572
  • Santulli G ; Nakashima R ; Yuan Q ; Marks AR
  • J Physiol 2017[May]; 595 (10 ): 3041-3051 PMID28303572 show ga
  • Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP(3) Rs) are calcium (Ca(2+) ) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca(2+) release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus.
  • |Animals [MESH]
  • |Blood Pressure [MESH]
  • |Calcium/metabolism/physiology [MESH]
  • |Diabetes Mellitus/metabolism [MESH]
  • |Heart/physiology [MESH]
  • |Humans [MESH]
  • |Inositol 1,4,5-Trisphosphate Receptors/*physiology [MESH]
  • |Muscle, Skeletal/metabolism/physiology [MESH]
  • |Myocardium/metabolism [MESH]


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