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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Physiol
2017 ; 595
(10
): 3041-3051
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Intracellular calcium release channels: an update
#MMPMID28303572
Santulli G
; Nakashima R
; Yuan Q
; Marks AR
J Physiol
2017[May]; 595
(10
): 3041-3051
PMID28303572
show ga
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP(3) Rs)
are calcium (Ca(2+) ) release channels on the endo/sarcoplasmic reticulum
(ER/SR). Here we summarize the latest advances in the field, describing the
recently discovered mechanistic roles of intracellular Ca(2+) release channels in
the regulation of mitochondrial fitness and endothelial function, providing novel
therapeutic options for the treatment of heart failure, hypertension, and
diabetes mellitus.