Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25210150
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25210150
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Lipid+Res
2015 ; 56
(6
): 1085-99
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Intestinal transport and metabolism of bile acids
#MMPMID25210150
Dawson PA
; Karpen SJ
J Lipid Res
2015[Jun]; 56
(6
): 1085-99
PMID25210150
show ga
In addition to their classical roles as detergents to aid in the process of
digestion, bile acids have been identified as important signaling molecules that
function through various nuclear and G protein-coupled receptors to regulate a
myriad of cellular and molecular functions across both metabolic and nonmetabolic
pathways. Signaling via these pathways will vary depending on the tissue and the
concentration and chemical structure of the bile acid species. Important
determinants of the size and composition of the bile acid pool are their
efficient enterohepatic recirculation, their host and microbial metabolism, and
the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the
luminal microbiota. This review focuses on the mammalian intestine, discussing
the physiology of bile acid transport, the metabolism of bile acids in the gut,
and new developments in our understanding of how intestinal metabolism,
particularly by the gut microbiota, affects bile acid signaling.
free
free
free
