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2015 ; 78
(3
): 232-8
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Intestinal microbiota and its relationship with necrotizing enterocolitis
#MMPMID25992911
Patel RM
; Denning PW
Pediatr Res
2015[Sep]; 78
(3
): 232-8
PMID25992911
show ga
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in
infants born prematurely. After birth, the neonatal gut must acquire a healthy
complement of commensal bacteria. Disruption or delay of this critical process,
leading to deficient or abnormal microbial colonization of the gut, has been
implicated as key risk factor in the pathogenesis of NEC. Conversely, a
beneficial complement of commensal intestinal microbiota may protect the immature
gut from inflammation and injury. Interventions aimed at providing or restoring a
healthy complement of commensal bacteria, such as probiotic therapy, are
currently the most promising treatment to prevent NEC. Shifting the balance of
intestinal microbiota from a pathogenic to protective complement of bacteria can
protect the gut from inflammation and subsequent injury that leads to NEC.
Herein, we review the relationship of intestinal microbiota and NEC in preterm
infants.