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2015 ; 125
(3
): 891-8
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Intestinal lipid-derived signals that sense dietary fat
#MMPMID25642767
DiPatrizio NV
; Piomelli D
J Clin Invest
2015[Mar]; 125
(3
): 891-8
PMID25642767
show ga
Fat is a vital macronutrient, and its intake is closely monitored by an array of
molecular sensors distributed throughout the alimentary canal. In the mouth,
dietary fat constituents such as mono- and diunsaturated fatty acids give rise to
taste signals that stimulate food intake, in part by enhancing the production of
lipid-derived endocannabinoid messengers in the gut. As fat-containing chyme
enters the small intestine, it causes the formation of anorexic lipid mediators,
such as oleoylethanolamide, which promote satiety. These anatomically and
functionally distinct responses may contribute to the homeostatic control and,
possibly, the pathological dysregulation of food intake.