Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26081073
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26081073
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Aging+(Albany+NY)
2015 ; 7
(6
): 370-82
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Interstitial pericytes decrease in aged mouse kidneys
#MMPMID26081073
Stefanska A
; Eng D
; Kaverina N
; Duffield JS
; Pippin JW
; Rabinovitch P
; Shankland SJ
Aging (Albany NY)
2015[Jun]; 7
(6
): 370-82
PMID26081073
show ga
With increasing age, the kidney undergoes characteristic changes in the
glomerular and tubulo-interstitial compartments, which are ultimately accompanied
by reduced kidney function. Studies have shown age-related loss of peritubular
vessels. Normal peritubular vessel tone, function and survival depend on
neighboring pericytes. Pericyte detachment leads to vascular damage, which can be
accompanied by their differentiation to fibroblasts and myofibroblasts, a state
that favors matrix production. To better understand the fate of pericytes in the
aged kidney, 27 month-old mice were studied. Compared to 3 month-old young adult
mice, aged kidneys showed a substantial decrease in capillaries, identified by
CD31 staining, in both cortex and medulla. This was accompanied by a marked
decrease in surrounding NG2+ / PDGFR?+ pericytes. This decrease was more
pronounced in the medulla. Capillaries devoid of pericytes were typically dilated
in aged mice. Aged kidneys were also characterized by interstitial fibrosis due
to increased collagen-I and -III staining. This was accompanied by an increase in
the number of pericytes that acquired a pro-fibrotic phenotype, identified by
increased PDGFR?+ / ?SMA+ staining. These findings are consistent with the
decline in kidney interstitial pericytes as a critical step in the development of
changes to the peritubular vasculature with aging, and accompanying fibrosis.
free
free
free
