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10.1186/s13073-017-0456-7 http://scihub22266oqcxt.onion/10.1186/s13073-017-0456-7 C5514472!5514472 !28720120     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28720120 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Med 2017 ; 9 (1 ): 65 Nephropedia Template TP {{tp|p=28720120 |t=2017. Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing |pdf=|usr=}}{{28720120 }} gab.com Text Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing JO: Genome Med http://www.kidney.de/pget.php?&tw=1&pmid=28720120 #FOAvip Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a number of genetic diseases. Sanger sequencing and next-generation short-read sequencing are unable to interrogate TRE reliably. We developed a novel algorithm called RepeatHMM to estimate repeat counts from long-read sequencing data. Evaluation on simulation data, real amplicon sequencing data on two repeat expansion disorders, and whole-genome sequencing data generated by PacBio and Oxford Nanopore technologies showed superior performance over competing approaches. We concluded that long-read sequencing coupled with RepeatHMM can estimate repeat counts on microsatellites and can interrogate the "unsequenceable" genomic trinucleotide repeat disorders. Twit Text FOAVip Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing ????Genome Med http://www.kidney.de/pget.php?&tw=1&pmid=28720120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28720120 #FOAvip English Wikipedia <ref>{{Cite pmid|28720120 }}</ref> Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing #MMPMID28720120 Liu Q ; Zhang P ; Wang D ; Gu W ; Wang K Genome Med 2017[Jul]; 9 (1 ): 65 PMID28720120 show ga Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a number of genetic diseases. Sanger sequencing and next-generation short-read sequencing are unable to interrogate TRE reliably. We developed a novel algorithm called RepeatHMM to estimate repeat counts from long-read sequencing data. Evaluation on simulation data, real amplicon sequencing data on two repeat expansion disorders, and whole-genome sequencing data generated by PacBio and Oxford Nanopore technologies showed superior performance over competing approaches. We concluded that long-read sequencing coupled with RepeatHMM can estimate repeat counts on microsatellites and can interrogate the "unsequenceable" genomic trinucleotide repeat disorders. |*Algorithms [MESH] |*Trinucleotide Repeats [MESH] |High-Throughput Nucleotide Sequencing/*methods [MESH] |Humans [MESH]Interrogating the "unsequenceable" genomic trinucleotide repeat disord(epmc).pdf DeepDyve Pubget Overpricing