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2013 ; 1829
(6-7
): 732-41
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Interplay between viruses and host mRNA degradation
#MMPMID23274304
Narayanan K
; Makino S
Biochim Biophys Acta
2013[Jun]; 1829
(6-7
): 732-41
PMID23274304
show ga
Messenger RNA degradation is a fundamental cellular process that plays a critical
role in regulating gene expression by controlling both the quality and the
abundance of mRNAs in cells. Naturally, viruses must successfully interface with
the robust cellular RNA degradation machinery to achieve an optimal balance
between viral and cellular gene expression and establish a productive infection
in the host. In the past several years, studies have discovered many elegant
strategies that viruses have evolved to circumvent the cellular RNA degradation
machinery, ranging from disarming the RNA decay pathways and co-opting the
factors governing cellular mRNA stability to promoting host mRNA degradation that
facilitates selective viral gene expression and alters the dynamics of
host-pathogen interaction. This review summarizes the current knowledge of the
multifaceted interaction between viruses and cellular mRNA degradation machinery
to provide an insight into the regulatory mechanisms that influence gene
expression in viral infections. This article is part of a Special Issue entitled:
RNA Decay mechanisms.