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10.1158/0008-5472.CAN-16-1647 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-1647 C5354977!5354977 !28246276     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28246276 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interplay between Immune Checkpoint Proteins and Cellular Metabolism |pdf=|usr=}}{{28246276 }} gab.com Text Interplay between Immune Checkpoint Proteins and Cellular Metabolism JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28246276 #FOAvip With the recent successes in immuno-oncology, renewed interest in the role of immune checkpoint modulators, such as the B7 family proteins, has escalated. The immune checkpoint proteins play a crucial role in the regulation of cellular immunity; however, their contribution to other aspects of cancer biology remains unclear. Accumulating evidence indicate that immune checkpoint proteins can regulate metabolic energetics of the tumor, the tumor microenvironment, and the tumor-specific immune response, leading to metabolic reprogramming of both malignant cells and immune cells involved in mounting and sustaining this response. Immune cell metabolism impacts the activation status of immune cells and ultimately the immune response in cancer. Tumor cells may deplete nutrients that immune cells require for optimal generation, expansion, and function. They may also generate toxic metabolites in the microenvironment or induce conserved inhibitory pathways that impair immune function and thus inhibit antitumor responses. In this review, we will discuss how cancer cells with altered expression of immune checkpoint proteins can potently inhibit immune function through the alteration of cellular and microenvironmental metabolism, providing a new perspective on the interplay between these pathways and offering a potential therapeutic intervention strategy in the treatment of malignant disease. Cancer Res; 77(6); 1245-9. ©2017 AACR. Twit Text FOAVip Interplay between Immune Checkpoint Proteins and Cellular Metabolism ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28246276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28246276 #FOAvip English Wikipedia <ref>{{Cite pmid|28246276 }}</ref> Interplay between Immune Checkpoint Proteins and Cellular Metabolism #MMPMID28246276 Lim S ; Phillips JB ; Madeira da Silva L ; Zhou M ; Fodstad O ; Owen LB ; Tan M Cancer Res 2017[Mar]; 77 (6 ): 1245-1249 PMID28246276 show ga With the recent successes in immuno-oncology, renewed interest in the role of immune checkpoint modulators, such as the B7 family proteins, has escalated. The immune checkpoint proteins play a crucial role in the regulation of cellular immunity; however, their contribution to other aspects of cancer biology remains unclear. Accumulating evidence indicate that immune checkpoint proteins can regulate metabolic energetics of the tumor, the tumor microenvironment, and the tumor-specific immune response, leading to metabolic reprogramming of both malignant cells and immune cells involved in mounting and sustaining this response. Immune cell metabolism impacts the activation status of immune cells and ultimately the immune response in cancer. Tumor cells may deplete nutrients that immune cells require for optimal generation, expansion, and function. They may also generate toxic metabolites in the microenvironment or induce conserved inhibitory pathways that impair immune function and thus inhibit antitumor responses. In this review, we will discuss how cancer cells with altered expression of immune checkpoint proteins can potently inhibit immune function through the alteration of cellular and microenvironmental metabolism, providing a new perspective on the interplay between these pathways and offering a potential therapeutic intervention strategy in the treatment of malignant disease. Cancer Res; 77(6); 1245-9. ©2017 AACR. |Animals [MESH] |Cell Cycle Checkpoints/*immunology [MESH] |Humans [MESH] |Immunity, Cellular/*immunology [MESH] |Neoplasms/*immunology/*metabolism/pathology [MESH]Interplay between Immune Checkpoint Proteins and Cellular Metabolism (epmc).pdf DeepDyve Pubget Overpricing