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2017 ; 614
(ä): 8-14
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Interluekin-17A (IL17A)
#MMPMID28122268
Chen K
; Kolls JK
Gene
2017[May]; 614
(ä): 8-14
PMID28122268
show ga
The discovery of the key roles of interleukin-17A (IL-17A) and IL-17A producing
cells in inflammation, autoimmune diseases and host defense has led to the
experimental targeting of the IL-17A pathway in animal models of diseases as well
as in clinical trials in humans. These therapeutic agents include biological
products that target IL-17A and IL-23, an upstream regulator of IL-17A
production. IL-17A producing T helper cells (Th17 cells) are a distinct lineage
from the Th1 and Th2 CD4+ lineages and have been suggested to represent a good
drug target in certain inflammatory conditions. Targeting IL-17A has been proven
to be a good approach as anti-IL-17A is FDA approved for the treatment of
psoriasis in 2015. In host defense, IL-17A has been shown to be mostly beneficial
against infection caused by extracellular bacteria and fungi. This review will
overview the discovery of IL-17A, the receptors used by this cytokine and its
role in mucosal immunity and inflammation.
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