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2014 ; 28
(ä): 102-6
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Interleukin 33: a switch-hitting cytokine
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Villarreal DO
; Weiner DB
Curr Opin Immunol
2014[Jun]; 28
(ä): 102-6
PMID24762410
show ga
For many years IL-33 has been widely studied in the context of T helper type 2
(Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a
cytokine with a plethora of pleiotropic properties. Depending on the immune cells
targeted by IL-33, it is reported to not only promote Th2 immunity, but also to
induce T helper type 1 (Th1) immunity. Furthermore, recent studies have revealed
that IL-33 can activate CD8(+) T cells. These new studies provide evidence for
its beneficial role in antiviral and antitumor immunity. Here we review the
evidence of IL-33 to drive protective T cell immunity plus its potential use as
an adjuvant in vaccination and tumor therapy.