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10.1016/j.coi.2014.03.004

http://scihub22266oqcxt.onion/10.1016/j.coi.2014.03.004
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suck abstract from ncbi


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      Curr+Opin+Immunol 2014 ; 28 (ä): 102-6
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  • Interleukin 33: a switch-hitting cytokine #MMPMID24762410
  • Villarreal DO ; Weiner DB
  • Curr Opin Immunol 2014[Jun]; 28 (ä): 102-6 PMID24762410 show ga
  • For many years IL-33 has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote Th2 immunity, but also to induce T helper type 1 (Th1) immunity. Furthermore, recent studies have revealed that IL-33 can activate CD8(+) T cells. These new studies provide evidence for its beneficial role in antiviral and antitumor immunity. Here we review the evidence of IL-33 to drive protective T cell immunity plus its potential use as an adjuvant in vaccination and tumor therapy.
  • |Animals [MESH]
  • |Cytokines/*immunology [MESH]
  • |Humans [MESH]
  • |Interleukins/*immunology [MESH]
  • |Neoplasms/immunology [MESH]
  • |Th1 Cells/immunology [MESH]


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