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10.1016/j.trecan.2016.07.006 http://scihub22266oqcxt.onion/10.1016/j.trecan.2016.07.006 C5305119!5305119 !28210711     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28210711 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Cancer 2016 ; 2 (9 ): 475-484 Nephropedia Template TP {{tp|p=28210711 |t=2016. Intergenically Spliced Chimeric RNAs in Cancer |pdf=|usr=}}{{28210711 }} gab.com Text Intergenically Spliced Chimeric RNAs in Cancer JO: Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28210711 #FOAvip Gene fusions and their encoded products (fusion RNAs and proteins) are viewed as one of the hallmarks of cancer. Traditionally, they were thought to be generated solely by chromosomal rearrangements. However, recent discoveries of trans-splicing and cis-splicing events between neighboring genes, suggest that there are other mechanisms to generate chimeric fusion RNAs without corresponding changes in DNA. In addition, chimeric RNAs have been detected in normal physiology, complicating the use of fusions in cancer detection and therapy. On the other hand, "intergenically spliced" fusion RNAs represent a new repertoire of biomarkers and therapeutic targets. Here, we review current knowledge on chimeric RNAs and implications for cancer detection and treatment, and discuss outstanding questions for the advancement of the field. Twit Text FOAVip Intergenically Spliced Chimeric RNAs in Cancer ????Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28210711 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28210711 #FOAvip English Wikipedia <ref>{{Cite pmid|28210711 }}</ref> Intergenically Spliced Chimeric RNAs in Cancer #MMPMID28210711 Jia Y ; Xie Z ; Li H Trends Cancer 2016[Sep]; 2 (9 ): 475-484 PMID28210711 show ga Gene fusions and their encoded products (fusion RNAs and proteins) are viewed as one of the hallmarks of cancer. Traditionally, they were thought to be generated solely by chromosomal rearrangements. However, recent discoveries of trans-splicing and cis-splicing events between neighboring genes, suggest that there are other mechanisms to generate chimeric fusion RNAs without corresponding changes in DNA. In addition, chimeric RNAs have been detected in normal physiology, complicating the use of fusions in cancer detection and therapy. On the other hand, "intergenically spliced" fusion RNAs represent a new repertoire of biomarkers and therapeutic targets. Here, we review current knowledge on chimeric RNAs and implications for cancer detection and treatment, and discuss outstanding questions for the advancement of the field. |*RNA Splicing [MESH] |Biomarkers, Tumor [MESH] |Gene Fusion [MESH] |Humans [MESH]Intergenically Spliced Chimeric RNAs in Cancer (epmc).pdf DeepDyve Pubget Overpricing