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2018 ; 9
(ä): 203
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Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective
#MMPMID29563876
Rémy B
; Mion S
; Plener L
; Elias M
; Chabrière E
; Daudé D
Front Pharmacol
2018[]; 9
(ä): 203
PMID29563876
show ga
Numerous bacteria utilize molecular communication systems referred to as quorum
sensing (QS) to synchronize the expression of certain genes regulating, among
other aspects, the expression of virulence factors and the synthesis of biofilm.
To achieve this process, bacteria use signaling molecules, known as autoinducers
(AIs), as chemical messengers to share information. Naturally occurring
strategies that interfere with bacterial signaling have been extensively studied
in recent years, examining their potential to control bacteria. To interfere with
QS, bacteria use quorum sensing inhibitors (QSIs) to block the action of AIs and
quorum quenching (QQ) enzymes to degrade signaling molecules. Recent studies have
shown that these strategies are promising routes to decrease bacterial
pathogenicity and decrease biofilms, potentially enhancing bacterial
susceptibility to antimicrobial agents including antibiotics and bacteriophages.
The efficacy of QSIs and QQ enzymes has been demonstrated in various animal
models and are now considered in the development of new medical devices against
bacterial infections, including dressings, and catheters for enlarging the
therapeutic arsenal against bacteria.