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2015 ; 89
(24
): 12242-4
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Intercellular Transmission of Viral Populations with Vesicles
#MMPMID26423944
Altan-Bonnet N
; Chen YH
J Virol
2015[Dec]; 89
(24
): 12242-4
PMID26423944
show ga
A common paradigm holds that during cell-to-cell transmission, viruses behave as
lone soldiers. Recently, we discovered not only that enteroviruses are
transmitted via vesicles as populations of viral particles but also that this
type of transmission enhances their infection efficiency (Y. H. Chen et al., Cell
160: 619-630, 2015). This mechanism could be advantageous for the overall fitness
of the viral population, promoting genetic interplay by enabling viral
quasispecies to collectively infect a susceptible host cell. Here, we discuss
these findings in the context of viral pathogenesis and also propose that this
novel type of vesicular transmission is widespread among different virus families
and includes populations of both viral particles and naked viral genomes.