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2012 ; 92
(3
): 1359-92
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Intercellular Ca(2+) waves: mechanisms and function
#MMPMID22811430
Leybaert L
; Sanderson MJ
Physiol Rev
2012[Jul]; 92
(3
): 1359-92
PMID22811430
show ga
Intercellular calcium (Ca(2+)) waves (ICWs) represent the propagation of
increases in intracellular Ca(2+) through a syncytium of cells and appear to be a
fundamental mechanism for coordinating multicellular responses. ICWs occur in a
wide diversity of cells and have been extensively studied in vitro. More recent
studies focus on ICWs in vivo. ICWs are triggered by a variety of stimuli and
involve the release of Ca(2+) from internal stores. The propagation of ICWs
predominately involves cell communication with internal messengers moving via gap
junctions or extracellular messengers mediating paracrine signaling. ICWs appear
to be important in both normal physiology as well as pathophysiological processes
in a variety of organs and tissues including brain, liver, retina, cochlea, and
vascular tissue. We review here the mechanisms of initiation and propagation of
ICWs, the key intra- and extracellular messengers (inositol 1,4,5-trisphosphate
and ATP) mediating ICWs, and the proposed physiological functions of ICWs.