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2016 ; 12
(7
): 884-97
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Interactions between Autophagy and Inhibitory Cytokines
#MMPMID27313501
Wu TT
; Li WM
; Yao YM
Int J Biol Sci
2016[]; 12
(7
): 884-97
PMID27313501
show ga
Autophagy is a degradative pathway that plays an essential role in maintaining
cellular homeostasis. Most early studies of autophagy focused on its involvement
in age-associated degeneration and nutrient deprivation. However, the
immunological functions of autophagy have become more widely studied in recent
years. Autophagy has been shown to be an intrinsic cellular defense mechanism in
the innate and adaptive immune responses. Cytokines belong to a broad and loose
category of proteins and are crucial for innate and adaptive immunity. Inhibitory
cytokines have evolved to permit tolerance to self while also contributing to the
eradication of invading pathogens. Interactions between inhibitory cytokines and
autophagy have recently been reported, revealing a novel mechanism by which
autophagy controls the immune response. In this review, we discuss interactions
between autophagy and the regulatory cytokines IL-10, transforming growth
factor-?, and IL-27. We also mention possible interactions between two newly
discovered cytokines, IL-35 and IL-37, and autophagy.