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Interaction of radiation therapy with molecular targeted agents
#MMPMID25113770
Morris ZS
; Harari PM
J Clin Oncol
2014[Sep]; 32
(26
): 2886-93
PMID25113770
show ga
The development of molecular targeted therapeutics in oncology builds on many
years of scientific investigation into the cellular mechanics of malignant
transformation and progression. The past two decades have brought an accelerating
pace to the clinical investigation of new molecular targeted agents, particularly
in the setting of metastatic disease. The integration of molecular targeted
agents into phase III clinical trial design has lagged in the curative treatment
setting, particularly in combination with established therapeutic modalities such
as radiation. In this review, we discuss the interaction of radiation and
molecular targeted therapeutics. The dynamics of cellular and tumor response to
radiation offer unique opportunities for beneficial interplay with molecular
targeted agents that may go unrecognized with conventional screening and
monotherapy clinical testing of novel agents. By using epidermal growth factor
receptor (EGFR) as a primary example, we discuss recent clinical studies that
illustrate the potential synergy of molecular targeted agents with radiation and
highlight the clinical value of such interactions. For various molecular targeted
agents, their greatest clinical impact may rest in combination with radiation,
and efforts to facilitate systematic investigation of this approach appear highly
warranted.
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