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10.1097/MOL.0000000000000106 http://scihub22266oqcxt.onion/10.1097/MOL.0000000000000106 C4219984!4219984 !25036592     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25036592 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25036592 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Lipidol 2014 ; 25 (5 ): 333-8 Nephropedia Template TP {{tp|p=25036592 |t=2014. Interaction of pathogens with host cholesterol metabolism |pdf=|usr=}}{{25036592 }} gab.com Text Interaction of pathogens with host cholesterol metabolism JO: Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=25036592 #FOAvip PURPOSE OF REVIEW: Pathogens of different taxa, from prions to protozoa, target cellular cholesterol metabolism to advance their own development and to impair host immune responses, but also causing metabolic complications, for example, atherosclerosis. This review describes recent findings of how pathogens do it. RECENT FINDINGS: A common theme in interaction between pathogens and host cholesterol metabolism is pathogens targeting lipid rafts of the host plasma membrane. Many intracellular pathogens use rafts as an entry gate, taking advantage of the endocytic machinery and high abundance of outward-looking molecules that can be used as receptors. At the same time, disruption of the rafts' functional capacity, achieved by the pathogens through a number of various means, impairs the ability of the host to generate immune response, thus helping pathogen to thrive. Pathogens cannot synthesize cholesterol, and salvaging host cholesterol helps pathogens build advanced cholesterol-containing membranes and assembly platforms. Impact on cholesterol metabolism is not limited to the infected cells; proteins and microRNAs secreted by infected cells affect lipid metabolism systemically. SUMMARY: Given an essential role that host cholesterol metabolism plays in pathogen development, targeting this interaction may be a viable strategy to fight infections, as well as metabolic complications of the infections. Twit Text FOAVip Interaction of pathogens with host cholesterol metabolism ????Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=25036592 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25036592 #FOAvip English Wikipedia <ref>{{Cite pmid|25036592 }}</ref> Interaction of pathogens with host cholesterol metabolism #MMPMID25036592 Sviridov D ; Bukrinsky M Curr Opin Lipidol 2014[Oct]; 25 (5 ): 333-8 PMID25036592 show ga PURPOSE OF REVIEW: Pathogens of different taxa, from prions to protozoa, target cellular cholesterol metabolism to advance their own development and to impair host immune responses, but also causing metabolic complications, for example, atherosclerosis. This review describes recent findings of how pathogens do it. RECENT FINDINGS: A common theme in interaction between pathogens and host cholesterol metabolism is pathogens targeting lipid rafts of the host plasma membrane. Many intracellular pathogens use rafts as an entry gate, taking advantage of the endocytic machinery and high abundance of outward-looking molecules that can be used as receptors. At the same time, disruption of the rafts' functional capacity, achieved by the pathogens through a number of various means, impairs the ability of the host to generate immune response, thus helping pathogen to thrive. Pathogens cannot synthesize cholesterol, and salvaging host cholesterol helps pathogens build advanced cholesterol-containing membranes and assembly platforms. Impact on cholesterol metabolism is not limited to the infected cells; proteins and microRNAs secreted by infected cells affect lipid metabolism systemically. SUMMARY: Given an essential role that host cholesterol metabolism plays in pathogen development, targeting this interaction may be a viable strategy to fight infections, as well as metabolic complications of the infections. |*Host-Pathogen Interactions [MESH] |Cholesterol/*metabolism [MESH] |Cytoplasm/metabolism/pathology [MESH] |Humans [MESH] |Infections/etiology/*metabolism/pathology [MESH] |Lipid Metabolism [MESH] |Membrane Microdomains/*metabolism/pathology [MESH] |MicroRNAs/genetics/metabolism [MESH]Interaction of pathogens with host cholesterol metabolism (epmc).pdf DeepDyve Pubget Overpricing