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2016 ; 14
(1
): 20
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Interaction of MSC with tumor cells
#MMPMID27608835
Melzer C
; Yang Y
; Hass R
Cell Commun Signal
2016[Sep]; 14
(1
): 20
PMID27608835
show ga
Tumor development and tumor progression is not only determined by the
corresponding tumor cells but also by the tumor microenvironment. This includes
an orchestrated network of interacting cell types (e.g. immune cells, endothelial
cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the
extracellular matrix and soluble factors such as cytokines, chemokines, growth
factors and various metabolites. Cell populations of the tumor microenvironment
can interact directly and indirectly with cancer cells by mutually altering
properties and functions of the involved partners. Particularly, mesenchymal
stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting
different types of intercellular communication. Accordingly, this work focusses
on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some
functional changes and consequences for both cell types are summarized which can
eventually result in the establishment of a carcinoma stem cell niche (CSCN) or
the generation of new tumor cell populations by MSC-tumor cell fusion.