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10.1128/MMBR.00056-13 http://scihub22266oqcxt.onion/10.1128/MMBR.00056-13 C4054258!4054258 !24847022     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24847022 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24847022 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microbiol+Mol+Biol+Rev 2014 ; 78 (2 ): 257-77 Nephropedia Template TP {{tp|p=24847022 |t=2014. Integrons: past, present, and future |pdf=|usr=}}{{24847022 }} gab.com Text Integrons: past, present, and future JO: Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=24847022 #FOAvip Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons requires an understanding of their origins and evolutionary history. This review examines the functions and activities of integrons before the antibiotic era. It shows how antibiotic use selected particular integrons from among the environmental pool of these elements, such that integrons carrying resistance genes are now present in the majority of Gram-negative pathogens. Finally, it examines the potential consequences of widespread pollution with the novel integrons that have been assembled via the agency of human antibiotic use and speculates on the potential uses of integrons as platforms for biotechnology. Twit Text FOAVip Integrons: past, present, and future ????Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=24847022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24847022 #FOAvip English Wikipedia <ref>{{Cite pmid|24847022 }}</ref> Integrons: past, present, and future #MMPMID24847022 Gillings MR Microbiol Mol Biol Rev 2014[Jun]; 78 (2 ): 257-77 PMID24847022 show ga Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons requires an understanding of their origins and evolutionary history. This review examines the functions and activities of integrons before the antibiotic era. It shows how antibiotic use selected particular integrons from among the environmental pool of these elements, such that integrons carrying resistance genes are now present in the majority of Gram-negative pathogens. Finally, it examines the potential consequences of widespread pollution with the novel integrons that have been assembled via the agency of human antibiotic use and speculates on the potential uses of integrons as platforms for biotechnology. |*DNA, Bacterial [MESH] |Bacteria/drug effects/*genetics/metabolism [MESH] |Drug Resistance, Bacterial/genetics [MESH] |Evolution, Molecular [MESH] |Gene Expression Regulation, Bacterial [MESH] |Gene Order [MESH] |Genome, Bacterial [MESH] |Homologous Recombination [MESH]Integrons: past, present, and future (epmc).pdf DeepDyve Pubget Overpricing