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10.1038/nrc2748 http://scihub22266oqcxt.onion/10.1038/nrc2748 C4383089!4383089 !20029421     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20029421 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Cancer 2010 ; 10 (1 ): 9-22 Nephropedia Template TP {{tp|p=20029421 |t=2010. Integrins in cancer: biological implications and therapeutic opportunities |pdf=|usr=}}{{20029421 }} gab.com Text Integrins in cancer: biological implications and therapeutic opportunities JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=20029421 #FOAvip The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation, progression and metastasis of solid tumours. The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy. Integrin antagonists, including the alphavbeta3 and alphavbeta5 inhibitor cilengitide, have shown encouraging activity in Phase II clinical trials and cilengitide is currently being tested in a Phase III trial in patients with glioblastoma. These exciting clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment. Twit Text FOAVip Integrins in cancer: biological implications and therapeutic opportunities ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=20029421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20029421 #FOAvip English Wikipedia <ref>{{Cite pmid|20029421 }}</ref> Integrins in cancer: biological implications and therapeutic opportunities #MMPMID20029421 Desgrosellier JS ; Cheresh DA Nat Rev Cancer 2010[Jan]; 10 (1 ): 9-22 PMID20029421 show ga The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation, progression and metastasis of solid tumours. The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy. Integrin antagonists, including the alphavbeta3 and alphavbeta5 inhibitor cilengitide, have shown encouraging activity in Phase II clinical trials and cilengitide is currently being tested in a Phase III trial in patients with glioblastoma. These exciting clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment. |Animals [MESH] |Apoptosis [MESH] |Clinical Trials as Topic [MESH] |Humans [MESH] |Integrins/antagonists & inhibitors/*metabolism/therapeutic use [MESH] |Neoplasms/*drug therapy/*metabolism/pathology/physiopathology [MESH]Integrins in cancer: biological implications and therapeutic opportuni(epmc).pdf DeepDyve Pubget Overpricing