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10.2174/1566524015666150921105339 http://scihub22266oqcxt.onion/10.2174/1566524015666150921105339 C5427774!5427774 !26391549     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26391549 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26391549 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Mol+Med 2015 ; 15 (8 ): 714-34 Nephropedia Template TP {{tp|p=26391549 |t=2015. Integrins as Therapeutic Targets for Respiratory Diseases |pdf=|usr=}}{{26391549 }} gab.com Text Integrins as Therapeutic Targets for Respiratory Diseases JO: Curr Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26391549 #FOAvip Integrins are a large family of transmembrane heterodimeric proteins that constitute the main receptors for extracellular matrix components. Integrins were initially thought to be primarily involved in the maintenance of cell adhesion and tissue integrity. However, it is now appreciated that integrins play important roles in many other biological processes such as cell survival, proliferation, differentiation, migration, cell shape and polarity. Lung cells express numerous combinations and permutations of integrin heterodimers. The complexity and diversity of different integrin heterodimers being implicated in different lung diseases present a major challenge for drug development. Here we provide a comprehensive overview of the current knowledge of integrins from studies in cell culture to integrin knockout mouse models and provide an update of results from clinical trials for which integrins are therapeutic targets with a focus on respiratory diseases (asthma, emphysema, pneumonia, lung cancer, pulmonary fibrosis and sarcoidosis). Twit Text FOAVip Integrins as Therapeutic Targets for Respiratory Diseases ????Curr Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26391549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26391549 #FOAvip English Wikipedia <ref>{{Cite pmid|26391549 }}</ref> Integrins as Therapeutic Targets for Respiratory Diseases #MMPMID26391549 Teoh CM ; Tan SS ; Tran T Curr Mol Med 2015[]; 15 (8 ): 714-34 PMID26391549 show ga Integrins are a large family of transmembrane heterodimeric proteins that constitute the main receptors for extracellular matrix components. Integrins were initially thought to be primarily involved in the maintenance of cell adhesion and tissue integrity. However, it is now appreciated that integrins play important roles in many other biological processes such as cell survival, proliferation, differentiation, migration, cell shape and polarity. Lung cells express numerous combinations and permutations of integrin heterodimers. The complexity and diversity of different integrin heterodimers being implicated in different lung diseases present a major challenge for drug development. Here we provide a comprehensive overview of the current knowledge of integrins from studies in cell culture to integrin knockout mouse models and provide an update of results from clinical trials for which integrins are therapeutic targets with a focus on respiratory diseases (asthma, emphysema, pneumonia, lung cancer, pulmonary fibrosis and sarcoidosis). |Airway Remodeling/genetics [MESH] |Animals [MESH] |Carrier Proteins/metabolism [MESH] |Cell Adhesion/genetics [MESH] |Cell Movement/genetics [MESH] |Cell Survival/genetics [MESH] |Clinical Trials as Topic [MESH] |Disease Models, Animal [MESH] |Extracellular Matrix/metabolism [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Integrins/antagonists & inhibitors/chemistry/*genetics/*metabolism [MESH] |Lung/metabolism/pathology [MESH] |Mice, Knockout [MESH] |Molecular Targeted Therapy [MESH] |Multigene Family [MESH] |Neovascularization, Pathologic [MESH] |Osteonectin/genetics/metabolism [MESH] |Phenotype [MESH] |Protein Binding [MESH] |Respiratory Tract Diseases/drug therapy/*etiology/*metabolism/pathology [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta/metabolism [MESH]Integrins as Therapeutic Targets for Respiratory Diseases (epmc).pdf DeepDyve Pubget Overpricing