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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Biol
2016 ; 215
(4
): 445-456
Nephropedia Template TP
J Cell Biol
2016[Nov]; 215
(4
): 445-456
PMID27872252
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Cells can detect and react to the biophysical properties of the extracellular
environment through integrin-based adhesion sites and adapt to the extracellular
milieu in a process called mechanotransduction. At these adhesion sites,
integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton
and transduce mechanical forces generated by the actin retrograde flow and myosin
II to the ECM through mechanosensitive focal adhesion proteins that are
collectively termed the "molecular clutch." The transmission of forces across
integrin-based adhesions establishes a mechanical reciprocity between the
viscoelasticity of the ECM and the cellular tension. During mechanotransduction,
force allosterically alters the functions of mechanosensitive proteins within
adhesions to elicit biochemical signals that regulate both rapid responses in
cellular mechanics and long-term changes in gene expression. Integrin-mediated
mechanotransduction plays important roles in development and tissue homeostasis,
and its dysregulation is often associated with diseases.
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