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2015 ; 63
(1-3
): 11-7
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Integrative neuroscience approach to neuropsychiatric lupus
#MMPMID26467973
Huerta PT
; Gibson EL
; Rey C
; Huerta TS
Immunol Res
2015[Dec]; 63
(1-3
): 11-7
PMID26467973
show ga
We present a succinct review of our approach to study the interactions between
the DNA-reactive antibodies that cross-react with the GluN2A and GluN2B subunits
of the N-methyl-D-aspartate receptor, denoted DNRABs, and their brain targets in
subjects with neuropsychiatric systemic lupus erythematosus (NPSLE). We have
analyzed the DNRAB-based brain symptomatology in mouse models of NPSLE by using
an integrative neuroscience approach, which includes behavioral assessment
coupled with electrophysiological studies of neural networks and synaptic
connections in target brain regions, such as the CA1 region of the hippocampus.
Our results suggest a framework for understanding the interactions between immune
factors and neural networks.