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Integration of mRNP formation and export
#MMPMID28314893
Björk P
; Wieslander L
Cell Mol Life Sci
2017[Aug]; 74
(16
): 2875-2897
PMID28314893
show ga
Expression of protein-coding genes in eukaryotes relies on the coordinated action
of many sophisticated molecular machineries. Transcription produces precursor
mRNAs (pre-mRNAs) and the active gene provides an environment in which the
pre-mRNAs are processed, folded, and assembled into RNA-protein (RNP) complexes.
The dynamic pre-mRNPs incorporate the growing transcript, proteins, and the
processing machineries, as well as the specific protein marks left after
processing that are essential for export and the cytoplasmic fate of the mRNPs.
After release from the gene, the mRNPs move by diffusion within the
interchromatin compartment, making up pools of mRNPs. Here, splicing and
polyadenylation can be completed and the mRNPs recruit the major export receptor
NXF1. Export competent mRNPs interact with the nuclear pore complex, leading to
export, concomitant with compositional and conformational changes of the mRNPs.
We summarize the integrated nuclear processes involved in the formation and
export of mRNPs.
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