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2016 ; 14
(5
): 4030-4036
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Insights into the pathogenesis of Mycoplasma pneumoniae (Review)
#MMPMID27667580
He J
; Liu M
; Ye Z
; Tan T
; Liu X
; You X
; Zeng Y
; Wu Y
Mol Med Rep
2016[Nov]; 14
(5
): 4030-4036
PMID27667580
show ga
Mycoplasma are the smallest prokaryotic microbes present in nature. These
wall?less, malleable organisms can pass through cell filters, and grow and
propagate under cell?free conditions in vitro. Of the pathogenic Mycoplasma
Mycoplasma pneumoniae has been examined the most. In addition to primary atypical
pneumonia and community?acquired pneumonia with predominantly respiratory
symptoms, M. pneumoniae can also induce autoimmune hemolytic anemia and other
diseases in the blood, cardiovascular system, gastrointestinal tract and skin,
and can induce pericarditis, myocarditis, nephritis and meningitis. The
pathogenesis of M. pneumoniae infection is complex and remains to be fully
elucidated. The present review aimed to summarize several direct damage
mechanisms, including adhesion damage, destruction of membrane fusion, nutrition
depletion, invasive damage, toxic damage, inflammatory damage and immune damage.
Further investigations are required for determining the detailed pathogenesis of
M. pneumoniae.