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Insights into epigenetic landscape of recombination-free regions
#MMPMID26801812
Termolino P
; Cremona G
; Consiglio MF
; Conicella C
Chromosoma
2016[Jun]; 125
(2
): 301-8
PMID26801812
show ga
Genome architecture is shaped by gene-rich and repeat-rich regions also known as
euchromatin and heterochromatin, respectively. Under normal conditions, the
repeat-containing regions undergo little or no meiotic crossover (CO)
recombination. COs within repeats are risky for the genome integrity. Indeed,
they can promote non-allelic homologous recombination (NAHR) resulting in
deleterious genomic rearrangements associated with diseases in humans. The
assembly of heterochromatin is driven by the combinatorial action of many factors
including histones, their modifications, and DNA methylation. In this review, we
discuss current knowledge dealing with the epigenetic signatures of the major
repeat regions where COs are suppressed. Then we describe mutants for
epiregulators of heterochromatin in different organisms to find out how chromatin
structure influences the CO rate and distribution.
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