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2016 ; 58
(ä): 102-18
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Insect immunology and hematopoiesis
#MMPMID26695127
Hillyer JF
Dev Comp Immunol
2016[May]; 58
(ä): 102-18
PMID26695127
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Insects combat infection by mounting powerful immune responses that are mediated
by hemocytes, the fat body, the midgut, the salivary glands and other tissues.
Foreign organisms that have entered the body of an insect are recognized by the
immune system when pathogen-associated molecular patterns bind host-derived
pattern recognition receptors. This, in turn, activates immune signaling pathways
that amplify the immune response, induce the production of factors with
antimicrobial activity, and activate effector pathways. Among the immune
signaling pathways are the Toll, Imd, Jak/Stat, JNK, and insulin pathways.
Activation of these and other pathways leads to pathogen killing via
phagocytosis, melanization, cellular encapsulation, nodulation, lysis,
RNAi-mediated virus destruction, autophagy and apoptosis. This review details
these and other aspects of immunity in insects, and discusses how the immune and
circulatory systems have co-adapted to combat infection, how hemocyte replication
and differentiation takes place (hematopoiesis), how an infection prepares an
insect for a subsequent infection (immune priming), how environmental factors
such as temperature and the age of the insect impact the immune response, and how
social immunity protects entire groups. Finally, this review highlights some
underexplored areas in the field of insect immunobiology.