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10.1016/bs.ai.2014.12.001

http://scihub22266oqcxt.onion/10.1016/bs.ai.2014.12.001
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suck abstract from ncbi


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pmid25727290
      Adv+Immunol 2015 ; 126 (ä): 173-213
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  • Innate memory T cells #MMPMID25727290
  • Jameson SC ; Lee YJ ; Hogquist KA
  • Adv Immunol 2015[]; 126 (ä): 173-213 PMID25727290 show ga
  • Memory T cells are usually considered to be a feature of a successful immune response against a foreign antigen, and such cells can mediate potent immunity. However, in mice, alternative pathways have been described, through which naïve T cells can acquire the characteristics and functions of memory T cells without encountering specific foreign antigen or the typical signals required for conventional T cell differentiation. Such cells reflect a response to the internal rather the external environment, and hence such cells are called innate memory T cells. In this review, we describe how innate memory subsets were identified, the signals that induce their generation and their functional properties and potential role in the normal immune response. The existence of innate memory T cells in mice raises questions about whether parallel populations exist in humans, and we discuss the evidence for such populations during human T cell development and differentiation.
  • |*Immunity, Innate [MESH]
  • |*Immunologic Memory [MESH]
  • |Animals [MESH]
  • |CD8-Positive T-Lymphocytes/*immunology [MESH]
  • |Cell Differentiation [MESH]
  • |Cytokines/immunology [MESH]
  • |Homeostasis [MESH]
  • |Humans [MESH]
  • |Lymphocyte Activation/immunology [MESH]
  • |Lymphopenia/immunology [MESH]
  • |Mice [MESH]
  • |Natural Killer T-Cells/*immunology [MESH]


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