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2015 ; 126
(ä): 173-213
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Innate memory T cells
#MMPMID25727290
Jameson SC
; Lee YJ
; Hogquist KA
Adv Immunol
2015[]; 126
(ä): 173-213
PMID25727290
show ga
Memory T cells are usually considered to be a feature of a successful immune
response against a foreign antigen, and such cells can mediate potent immunity.
However, in mice, alternative pathways have been described, through which naïve T
cells can acquire the characteristics and functions of memory T cells without
encountering specific foreign antigen or the typical signals required for
conventional T cell differentiation. Such cells reflect a response to the
internal rather the external environment, and hence such cells are called innate
memory T cells. In this review, we describe how innate memory subsets were
identified, the signals that induce their generation and their functional
properties and potential role in the normal immune response. The existence of
innate memory T cells in mice raises questions about whether parallel populations
exist in humans, and we discuss the evidence for such populations during human T
cell development and differentiation.