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10.1016/j.virol.2015.03.013 http://scihub22266oqcxt.onion/10.1016/j.virol.2015.03.013 C4424081!4424081 !25816762     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25816762 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2015 ; 479-480 (ä): 146-52 Nephropedia Template TP {{tp|p=25816762 |t=2015. Innate immune recognition of DNA: A recent history |pdf=|usr=}}{{25816762 }} gab.com Text Innate immune recognition of DNA: A recent history JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=25816762 #FOAvip Innate immune DNA sensing underpins many physiological and pathological responses to DNA, including anti-viral immunity to DNA viruses. Although it has been appreciated for many years that cytosolic DNA can evoke a type I interferon response, it is only within the past decade that the cellular mechanisms responsible for such a response have been defined. Here we review the discoveries that led to an appreciation of the existence of cytosolic DNA sensor proteins, and discuss two key such sensors, cGAS and IFI16, in detail. DNA sensors operate via STING, a protein shown to have a central role in controlling altered gene induction in response to DNA in vivo, and as such to be central to a rapidly expanding list of both protective and harmful responses to DNA. We also discuss recent insights into how and when DNA stimulates innate immunity, and highlight current outstanding questions in the DNA sensing field. Twit Text FOAVip Innate immune recognition of DNA: A recent history ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=25816762 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25816762 #FOAvip English Wikipedia <ref>{{Cite pmid|25816762 }}</ref> Innate immune recognition of DNA: A recent history #MMPMID25816762 Dempsey A ; Bowie AG Virology 2015[May]; 479-480 (ä): 146-52 PMID25816762 show ga Innate immune DNA sensing underpins many physiological and pathological responses to DNA, including anti-viral immunity to DNA viruses. Although it has been appreciated for many years that cytosolic DNA can evoke a type I interferon response, it is only within the past decade that the cellular mechanisms responsible for such a response have been defined. Here we review the discoveries that led to an appreciation of the existence of cytosolic DNA sensor proteins, and discuss two key such sensors, cGAS and IFI16, in detail. DNA sensors operate via STING, a protein shown to have a central role in controlling altered gene induction in response to DNA in vivo, and as such to be central to a rapidly expanding list of both protective and harmful responses to DNA. We also discuss recent insights into how and when DNA stimulates innate immunity, and highlight current outstanding questions in the DNA sensing field. |*Immunity, Innate [MESH] |Cytosol/immunology [MESH] |DNA/*immunology/metabolism [MESH] |Humans [MESH] |Membrane Proteins/immunology/metabolism [MESH]Innate immune recognition of DNA: A recent history (epmc).pdf DeepDyve Pubget Overpricing