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2017 ; 9
(3
): 271-280
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Innate Lung Defense during Invasive Aspergillosis: New Mechanisms
#MMPMID28231567
Garth JM
; Steele C
J Innate Immun
2017[]; 9
(3
): 271-280
PMID28231567
show ga
Invasive aspergillosis (IA) is one of the most difficult to treat and,
consequently, one of the most lethal fungal infections known to man. Continued
use of immunosuppressive agents during chemotherapy and organ transplantation
often leads to the development of neutropenia, the primary risk factor for IA.
However, IA is also becoming more appreciated in chronic diseases associated with
corticosteroid therapy. The innate immune response to Aspergillus fumigatus, the
primary agent in IA, plays a pivotal role in the recognition and elimination of
organisms from the pulmonary system. This review highlights recent findings about
innate host defense mechanisms, including novel aspects of innate cellular
immunity and pathogen recognition, and the inflammatory mediators that control
infection with A. fumigatus.