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2017 ; 8
(ä): 527
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Innate Immune Function of Mitochondrial Metabolism
#MMPMID28533780
Sancho D
; Enamorado M
; Garaude J
Front Immunol
2017[]; 8
(ä): 527
PMID28533780
show ga
Sensing of microbe-associated molecular patterns or danger signals by innate
immune receptors drives a complex exchange of information. Innate receptor
signaling not only triggers transcriptional events but also induces profound
changes in metabolic fluxes, redox balance, and metabolite abundance thereby
influencing immune cell function. Mitochondria are at the core of metabolic
adaptation to the changing environment. The close interaction between
mitochondrial metabolism and immune signaling has emerged as a central regulator
of innate sensing. Metabolic processes generate a constant flow of electrons that
eventually end up in the mitochondrial electron transport chain (ETC). Two
electron carriers and four respiratory complexes that can assemble as larger
molecular supercomplexes compose the ETC in the mitochondrial inner membrane.
While the meaning and biological relevance of such structural organization is a
matter of passionate debates, recent data support that innate stimuli remodel the
ETC. We will review the function of mitochondrial metabolism and ETC dynamics as
innate rheostats that regulate signaling, transcription, and epigenetics to
orchestrate innate immune responses.