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2014 ; 5
(6
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Innate Defense against Fungal Pathogens
#MMPMID25384766
Drummond RA
; Gaffen SL
; Hise AG
; Brown GD
Cold Spring Harb Perspect Med
2014[Nov]; 5
(6
): ä PMID25384766
show ga
Human fungal infections have been on the rise in recent years and proved
increasingly difficult to treat as a result of the lack of diagnostics, effective
antifungal therapies, and vaccines. Most pathogenic fungi do not cause disease
unless there is a disturbance in immune homeostasis, which can be caused by
modern medical interventions, disease-induced immunosuppression, and naturally
occurring human mutations. The innate immune system is well equipped to recognize
and destroy pathogenic fungi through specialized cells expressing a broad range
of pattern recognition receptors (PRRs). This review will outline the cells and
PRRs required for effective antifungal immunity, with a special focus on the
major antifungal cytokine IL-17 and recently characterized antifungal
inflammasomes.
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