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10.1038/cdd.2017.65 http://scihub22266oqcxt.onion/10.1038/cdd.2017.65 C5520172!5520172 !28498367     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28498367 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Differ 2017 ; 24 (7 ): 1184-1195 Nephropedia Template TP {{tp|p=28498367 |t=2017. Initiation and execution mechanisms of necroptosis: an overview |pdf=|usr=}}{{28498367 }} gab.com Text Initiation and execution mechanisms of necroptosis: an overview JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28498367 #FOAvip Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF family death domain receptors, pattern recognizing receptors and virus sensors. The common feature of these receptor systems is the implication of proteins, which contain a receptor interaction protein kinase (RIPK) homology interaction motif (RHIM) mediating recruitment and activation of receptor-interacting protein kinase 3 (RIPK3), which ultimately activates the necroptosis executioner mixed lineage kinase domain-like (MLKL). In case of the TNF family members, the initiator is the survival- and cell death-regulating RIPK1 kinase, in the case of Toll-like receptor 3/4 (TLR3/4), a RHIM-containing adaptor, called TRIF, while in the case of Z-DNA-binding protein ZBP1/DAI, the cytosolic viral sensor itself contains a RHIM domain. In this review, we discuss the different protein complexes that serve as nucleation platforms for necroptosis and the mechanism of execution of necroptosis. Transgenic models (knockout, kinase-dead knock-in) and pharmacologic inhibition indicate that RIPK1, RIPK3 or MLKL are implicated in many inflammatory, degenerative and infectious diseases. However, the conclusion of necroptosis being solely involved in the etiology of diseases is blurred by the pleiotropic roles of RIPK1 and RIPK3 in other cellular processes such as apoptosis and inflammasome activation. Twit Text FOAVip Initiation and execution mechanisms of necroptosis: an overview ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28498367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28498367 #FOAvip English Wikipedia <ref>{{Cite pmid|28498367 }}</ref> Initiation and execution mechanisms of necroptosis: an overview #MMPMID28498367 Grootjans S ; Vanden Berghe T ; Vandenabeele P Cell Death Differ 2017[Jul]; 24 (7 ): 1184-1195 PMID28498367 show ga Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF family death domain receptors, pattern recognizing receptors and virus sensors. The common feature of these receptor systems is the implication of proteins, which contain a receptor interaction protein kinase (RIPK) homology interaction motif (RHIM) mediating recruitment and activation of receptor-interacting protein kinase 3 (RIPK3), which ultimately activates the necroptosis executioner mixed lineage kinase domain-like (MLKL). In case of the TNF family members, the initiator is the survival- and cell death-regulating RIPK1 kinase, in the case of Toll-like receptor 3/4 (TLR3/4), a RHIM-containing adaptor, called TRIF, while in the case of Z-DNA-binding protein ZBP1/DAI, the cytosolic viral sensor itself contains a RHIM domain. In this review, we discuss the different protein complexes that serve as nucleation platforms for necroptosis and the mechanism of execution of necroptosis. Transgenic models (knockout, kinase-dead knock-in) and pharmacologic inhibition indicate that RIPK1, RIPK3 or MLKL are implicated in many inflammatory, degenerative and infectious diseases. However, the conclusion of necroptosis being solely involved in the etiology of diseases is blurred by the pleiotropic roles of RIPK1 and RIPK3 in other cellular processes such as apoptosis and inflammasome activation. |*Apoptosis [MESH] |Amyloid/metabolism [MESH] |Animals [MESH] |Humans [MESH] |Models, Biological [MESH] |Necrosis [MESH] |Receptor-Interacting Protein Serine-Threonine Kinases/metabolism [MESH]Initiation and execution mechanisms of necroptosis: an overview (epmc).pdf DeepDyve Pubget Overpricing