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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Pediatr+Surg
2016 ; 51
(6
): 981-5
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Initial diagnostic management of pediatric bone tumors
#MMPMID26995522
Interiano RB
; Malkan AD
; Loh AH
; Hinkle N
; Wahid FN
; Bahrami A
; Mao S
; Wu J
; Bishop MW
; Neel MD
; Gold RE
; Rao BN
; Davidoff AM
; Fernandez-Pineda I
J Pediatr Surg
2016[Jun]; 51
(6
): 981-5
PMID26995522
show ga
BACKGROUND: Osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are
the most common primary pediatric bone malignancies. We sought to assess the
diagnostic accuracy of initial tumor biopsies in patients with OS or ESFT at a
pediatric cancer center. METHODS: All biopsies performed at initial presentation
of patients with OS or ESFT at our institution from 2003 to 2012 were
retrospectively reviewed. Diagnostic accuracy and incidence of complications were
correlated with study variables using logistic regression analysis. RESULTS: One
hundred forty-two biopsies were performed in 105 patients (median age 13.4years,
range: 1.8-23.0), 104 (73.2%) OS and 38 (27.8%) ESFT. Thirty-one (21.8%) were
performed on metastatic sites. Eighty-five (76.6%) of 111 primary site biopsies
were open procedures, and 26 were percutaneous (23.4%). Primary site biopsies
were successful in 94.1% of open and 73.1% of percutaneous procedures. Odds of
obtaining a successful diagnostic specimen were 7.8 times higher with open
approach (CI: 1.6-36.8). Metastatic site biopsies were successful in 66.7% of
percutaneous and 100% of open and thoracoscopic procedures. CONCLUSION: Biopsy of
metastatic sites was equal to primary site in obtaining diagnostic material with
the added benefit of accurate staging, with few adverse events and high
diagnostic yield.