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2016 ; 10
(ä): 35
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Inhibitory Circuits in Cortical Layer 5
#MMPMID27199675
Naka A
; Adesnik H
Front Neural Circuits
2016[]; 10
(ä): 35
PMID27199675
show ga
Inhibitory neurons play a fundamental role in cortical computation and behavior.
Recent technological advances, such as two photon imaging, targeted in vivo
recording, and molecular profiling, have improved our understanding of the
function and diversity of cortical interneurons, but for technical reasons most
work has been directed towards inhibitory neurons in the superficial cortical
layers. Here we review current knowledge specifically on layer 5 (L5) inhibitory
microcircuits, which play a critical role in controlling cortical output. We
focus on recent work from the well-studied rodent barrel cortex, but also draw on
evidence from studies in primary visual cortex and other cortical areas. The
diversity of both deep inhibitory neurons and their pyramidal cell targets make
this a challenging but essential area of study in cortical computation and
sensory processing.