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10.1016/s0192-0561(99)00058-2 http://scihub22266oqcxt.onion/10.1016/s0192-0561(99)00058-2 10684994!ä!10684994 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\10684994.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Immunopharmacol 2000 ; 22 (2): 105-11 Nephropedia Template TP {{tp|p=10684994|t=2000. Inhibition of influenza virus replication by cocaine |pdf=|usr=}}{{10684994}} gab.com Text Inhibition of influenza virus replication by cocaine JO: Int J Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=10684994 #FOAvip Cocaine has been shown to have a number of diverse effects on the immune system. The current investigators have previously demonstrated an inhibitory effect of cocaine on murine hepatitis virus replication in peritoneal macrophages in vitro. The present study was undertaken to examine the effects of cocaine on influenza virus replication and to further characterize that effect in an animal model. Cocaine was capable of inducing a dose-dependent reduction in influenza PR-8 replication using MDCK cells in vitro. Concentrations of 100 microg/ml caused a 50% reduction of virus. To further characterize the effect in vivo, C57Bl/6 mice infected with influenza PR-8 by intranasal instillation were given daily ip injections of 10 mg/kg cocaine just prior to and for 4 days after exposure to influenza. Lungs from mice exposed to cocaine had viral titers that were reduced approximately 50% compared to controls as demonstrated by hemagglutination titers. Additional studies suggest that this reduction appears to be caused by an increase of cocaine-induced interferon. Twit Text FOAVip Inhibition of influenza virus replication by cocaine ????Int J Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=10684994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10684994 #FOAvip English Wikipedia <ref>{{Cite pmid|10684994}}</ref> Inhibition of influenza virus replication by cocaine #MMPMID10684994 Grattendick K; Lefkowitz DL; Lefkowitz SS Int J Immunopharmacol 2000[Feb]; 22 (2): 105-11 PMID10684994show ga Cocaine has been shown to have a number of diverse effects on the immune system. The current investigators have previously demonstrated an inhibitory effect of cocaine on murine hepatitis virus replication in peritoneal macrophages in vitro. The present study was undertaken to examine the effects of cocaine on influenza virus replication and to further characterize that effect in an animal model. Cocaine was capable of inducing a dose-dependent reduction in influenza PR-8 replication using MDCK cells in vitro. Concentrations of 100 microg/ml caused a 50% reduction of virus. To further characterize the effect in vivo, C57Bl/6 mice infected with influenza PR-8 by intranasal instillation were given daily ip injections of 10 mg/kg cocaine just prior to and for 4 days after exposure to influenza. Lungs from mice exposed to cocaine had viral titers that were reduced approximately 50% compared to controls as demonstrated by hemagglutination titers. Additional studies suggest that this reduction appears to be caused by an increase of cocaine-induced interferon. |Animals[MESH] |Cell Line[MESH] |Cocaine/*pharmacology[MESH] |Dogs[MESH] |Dose-Response Relationship, Drug[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Orthomyxoviridae/*drug effects/physiology[MESH]Inhibition of influenza virus replication by cocaine (epmc).pdf DeepDyve Pubget Overpricing