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10.1038/pr.2015.247 http://scihub22266oqcxt.onion/10.1038/pr.2015.247 C4821713!4821713 !26595536     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26595536 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pediatr+Res 2016 ; 79 (3 ): 378-86 Nephropedia Template TP {{tp|p=26595536 |t=2016. Inherited disorders of bilirubin clearance |pdf=|usr=}}{{26595536 }} gab.com Text Inherited disorders of bilirubin clearance JO: Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=26595536 #FOAvip Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (Dubin-Johnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome). In this review, the molecular mechanisms and clinical manifestations of these conditions are described, as well as current approaches to diagnosis and therapy. Twit Text FOAVip Inherited disorders of bilirubin clearance ????Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=26595536 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26595536 #FOAvip English Wikipedia <ref>{{Cite pmid|26595536 }}</ref> Inherited disorders of bilirubin clearance #MMPMID26595536 Memon N ; Weinberger BI ; Hegyi T ; Aleksunes LM Pediatr Res 2016[Mar]; 79 (3 ): 378-86 PMID26595536 show ga Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (Dubin-Johnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome). In this review, the molecular mechanisms and clinical manifestations of these conditions are described, as well as current approaches to diagnosis and therapy. |Animals [MESH] |Bile/chemistry [MESH] |Bilirubin/*blood/chemistry/metabolism [MESH] |Crigler-Najjar Syndrome/genetics [MESH] |Gilbert Disease/genetics [MESH] |Glucuronic Acid/chemistry [MESH] |Glucuronosyltransferase/genetics [MESH] |Humans [MESH] |Hyperbilirubinemia, Hereditary/diagnosis/*genetics [MESH] |Hyperbilirubinemia, Neonatal/diagnosis/*genetics [MESH] |Jaundice, Chronic Idiopathic/genetics [MESH]Inherited disorders of bilirubin clearance (epmc).pdf DeepDyve Pubget Overpricing