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10.1038/s41598-017-16166-y http://scihub22266oqcxt.onion/10.1038/s41598-017-16166-y C5698458!5698458 !29162874     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29162874 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29162874 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 15926 Nephropedia Template TP {{tp|p=29162874 |t=2017. Information processing in the NF-?B pathway |pdf=|usr=}}{{29162874 }} gab.com Text Information processing in the NF- B pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162874 #FOAvip The NF-?B pathway is known to transmit merely 1?bit of information about stimulus level. We combined experimentation with mathematical modeling to elucidate how information about TNF concentration is turned into a binary decision. Using Kolmogorov-Smirnov distance, we quantified the cell's ability to discern 8 TNF concentrations at each step of the NF-?B pathway, to find that input discernibility decreases as signal propagates along the pathway. Discernibility of low TNF concentrations is restricted by noise at the TNF receptor level, whereas discernibility of high TNF concentrations it is restricted by saturation/depletion of downstream signaling components. Consequently, signal discernibility is highest between 0.03 and 1 ng/ml TNF. Simultaneous exposure to TNF or LPS and a translation inhibitor, cycloheximide, leads to prolonged NF-?B activation and a marked increase of transcript levels of NF-?B inhibitors, I?B? and A20. The impact of cycloheximide becomes apparent after the first peak of nuclear NF-?B translocation, meaning that the NF-?B network not only relays 1?bit of information to coordinate the all-or-nothing expression of early genes, but also over a longer time course integrates information about other stimuli. The NF-?B system should be thus perceived as a feedback-controlled decision-making module rather than a simple information transmission channel. Twit Text FOAVip Information processing in the NF- B pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29162874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29162874 #FOAvip English Wikipedia <ref>{{Cite pmid|29162874 }}</ref> Information processing in the NF-?B pathway #MMPMID29162874 Tudelska K ; Markiewicz J ; Kocha?czyk M ; Czerkies M ; Prus W ; Korwek Z ; Abdi A ; B?o?ski S ; Ka?mierczak B ; Lipniacki T Sci Rep 2017[Nov]; 7 (1 ): 15926 PMID29162874 show ga The NF-?B pathway is known to transmit merely 1?bit of information about stimulus level. We combined experimentation with mathematical modeling to elucidate how information about TNF concentration is turned into a binary decision. Using Kolmogorov-Smirnov distance, we quantified the cell's ability to discern 8 TNF concentrations at each step of the NF-?B pathway, to find that input discernibility decreases as signal propagates along the pathway. Discernibility of low TNF concentrations is restricted by noise at the TNF receptor level, whereas discernibility of high TNF concentrations it is restricted by saturation/depletion of downstream signaling components. Consequently, signal discernibility is highest between 0.03 and 1 ng/ml TNF. Simultaneous exposure to TNF or LPS and a translation inhibitor, cycloheximide, leads to prolonged NF-?B activation and a marked increase of transcript levels of NF-?B inhibitors, I?B? and A20. The impact of cycloheximide becomes apparent after the first peak of nuclear NF-?B translocation, meaning that the NF-?B network not only relays 1?bit of information to coordinate the all-or-nothing expression of early genes, but also over a longer time course integrates information about other stimuli. The NF-?B system should be thus perceived as a feedback-controlled decision-making module rather than a simple information transmission channel. |*Electronic Data Processing [MESH] |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Cytoplasm/metabolism [MESH] |Fluorescence [MESH] |Lipopolysaccharides/pharmacology [MESH] |Mice [MESH] |NF-kappa B/*metabolism [MESH] |Protein Biosynthesis/drug effects [MESH] |Time Factors [MESH]Information processing in the NF-?B pathway (epmc).pdf DeepDyve Pubget Overpricing