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2015 ; 309
(10
): L1041-6
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Influenza lung injury: mechanisms and therapeutic opportunities
#MMPMID26408556
Gregory DJ
; Kobzik L
Am J Physiol Lung Cell Mol Physiol
2015[Nov]; 309
(10
): L1041-6
PMID26408556
show ga
In this Perspectives, we discuss some recent developments in the pathogenesis of
acute lung injury following influenza infection, with an emphasis on promising
therapeutic leads. Damage to the alveolar-capillary barrier has been quantified
in mice, and agents have been identified that can help to preserve barrier
integrity, such as vasculotide, angiopoietin-like 4 neutralization, and
sphingosine 1-phosphate mimics. Results from studies using mesenchymal stem cells
have been disappointing, despite promising data in other types of lung injury.
The roles of fatty acid binding protein 5, prostaglandin E2, and the interplay
between IFN-? and STAT1 in epithelial signaling during infection have been
addressed in vitro. Finally, we discuss the role of autophagy in inflammatory
cytokine production and the viral life cycle and the opportunities this presents
for intervention.
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