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10.1038/nmicrobiol.2016.69 http://scihub22266oqcxt.onion/10.1038/nmicrobiol.2016.69 C4917225!4917225 !27572970     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27572970 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27572970 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Microbiol 2016 ; 1 (7 ): 16069 Nephropedia Template TP {{tp|p=27572970 |t=2016. Influenza virus mRNA trafficking through host nuclear speckles |pdf=|usr=}}{{27572970 }} gab.com Text Influenza virus mRNA trafficking through host nuclear speckles JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27572970 #FOAvip Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are critical mediators of viral trafficking and budding. We show that the influenza virus uses nuclear speckles to promote post-transcriptional splicing of its M1 mRNA. We assign previously unknown roles for the viral NS1 protein and cellular factors to an intranuclear trafficking pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bodies and exports the spliced M2 mRNA from the nucleus. Given that nuclear speckles are storage sites for splicing factors, which leave these sites to splice cellular pre-mRNAs at transcribing genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression. Twit Text FOAVip Influenza virus mRNA trafficking through host nuclear speckles ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=27572970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27572970 #FOAvip English Wikipedia <ref>{{Cite pmid|27572970 }}</ref> Influenza virus mRNA trafficking through host nuclear speckles #MMPMID27572970 Mor A ; White A ; Zhang K ; Thompson M ; Esparza M ; Muñoz-Moreno R ; Koide K ; Lynch KW ; García-Sastre A ; Fontoura BM Nat Microbiol 2016[May]; 1 (7 ): 16069 PMID27572970 show ga Influenza A virus is a human pathogen with a genome composed of eight viral RNA segments that replicate in the nucleus. Two viral mRNAs are alternatively spliced. The unspliced M1 mRNA is translated into the matrix M1 protein, while the ion channel M2 protein is generated after alternative splicing. These proteins are critical mediators of viral trafficking and budding. We show that the influenza virus uses nuclear speckles to promote post-transcriptional splicing of its M1 mRNA. We assign previously unknown roles for the viral NS1 protein and cellular factors to an intranuclear trafficking pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bodies and exports the spliced M2 mRNA from the nucleus. Given that nuclear speckles are storage sites for splicing factors, which leave these sites to splice cellular pre-mRNAs at transcribing genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression. |*RNA Splicing [MESH] |Alternative Splicing [MESH] |Cell Line [MESH] |Cell Nucleus/*virology [MESH] |Gene Expression Regulation, Viral [MESH] |Genome, Viral [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Influenza A virus/*genetics/pathogenicity/physiology [MESH] |Intranuclear Inclusion Bodies/*metabolism/virology [MESH] |RNA, Viral/genetics/*metabolism [MESH] |Viral Matrix Proteins/*genetics/metabolism [MESH] |Viral Nonstructural Proteins/genetics/metabolism [MESH]Influenza virus mRNA trafficking through host nuclear speckles (epmc).pdf DeepDyve Pubget Overpricing