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10.1371/journal.ppat.1006588 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006588 C5587344!5587344 !28837667     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28837667 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28837667 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2017 ; 13 (8 ): e1006588 Nephropedia Template TP {{tp|p=28837667 |t=2017. Influenza NS1 directly modulates Hedgehog signaling during infection |pdf=|usr=}}{{28837667 }} gab.com Text Influenza NS1 directly modulates Hedgehog signaling during infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28837667 #FOAvip The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epistasis experiments and FRET-FLIM assays in Drosophila suggest that NS1 interacts directly with the transcriptional mediator, Ci/Gli1. We further confirmed that Hh target genes are activated cell-autonomously in transfected human lung epithelial cells expressing NS1, and in infected mouse lungs. We identified a point mutation in NS1, A122V, that modulates this activity in a context-dependent fashion. When the A122V mutation was incorporated into a mouse-adapted influenza A virus, it cell-autonomously enhanced expression of some Hh targets in the mouse lung, including IL6, and hastened lethality. These results indicate that, in addition to its multiple intracellular functions, NS1 also modifies a highly conserved signaling pathway, at least in part via cell autonomous activities. We discuss how this new Hh modulating function of NS1 may influence host lethality, possibly through controlling cytokine production, and how these new insights provide potential strategies for combating infection. Twit Text FOAVip Influenza NS1 directly modulates Hedgehog signaling during infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28837667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28837667 #FOAvip English Wikipedia <ref>{{Cite pmid|28837667 }}</ref> Influenza NS1 directly modulates Hedgehog signaling during infection #MMPMID28837667 Smelkinson MG ; Guichard A ; Teijaro JR ; Malur M ; Loureiro ME ; Jain P ; Ganesan S ; Zúñiga EI ; Krug RM ; Oldstone MB ; Bier E PLoS Pathog 2017[Aug]; 13 (8 ): e1006588 PMID28837667 show ga The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epistasis experiments and FRET-FLIM assays in Drosophila suggest that NS1 interacts directly with the transcriptional mediator, Ci/Gli1. We further confirmed that Hh target genes are activated cell-autonomously in transfected human lung epithelial cells expressing NS1, and in infected mouse lungs. We identified a point mutation in NS1, A122V, that modulates this activity in a context-dependent fashion. When the A122V mutation was incorporated into a mouse-adapted influenza A virus, it cell-autonomously enhanced expression of some Hh targets in the mouse lung, including IL6, and hastened lethality. These results indicate that, in addition to its multiple intracellular functions, NS1 also modifies a highly conserved signaling pathway, at least in part via cell autonomous activities. We discuss how this new Hh modulating function of NS1 may influence host lethality, possibly through controlling cytokine production, and how these new insights provide potential strategies for combating infection. |Animals [MESH] |Drosophila [MESH] |Hedgehog Proteins/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Influenza A Virus, H5N1 Subtype/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Orthomyxoviridae Infections/*metabolism [MESH] |Signal Transduction/*physiology [MESH]Influenza NS1 directly modulates Hedgehog signaling during infection (epmc).pdf DeepDyve Pubget Overpricing