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2018 ; 7
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Influence of Vitamin C on Lymphocytes: An Overview
#MMPMID29534432
van Gorkom GNY
; Klein Wolterink RGJ
; Van Elssen CHMJ
; Wieten L
; Germeraad WTV
; Bos GMJ
Antioxidants (Basel)
2018[Mar]; 7
(3
): ä PMID29534432
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Vitamin C or ascorbic acid (AA) is implicated in many biological processes and
has been proposed as a supplement for various conditions, including cancer. In
this review, we discuss the effects of AA on the development and function of
lymphocytes. This is important in the light of cancer treatment, as the immune
system needs to regenerate following chemotherapy or stem cell transplantation,
while cancer patients are often AA-deficient. We focus on lymphocytes, as these
white blood cells are the slowest to restore, rendering patients susceptible to
often lethal infections. T lymphocytes mediate cellular immunity and have been
most extensively studied in the context of AA biology. In vitro studies
demonstrate that T cell development requires AA, while AA also enhances T cell
proliferation and may influence T cell function. There are limited and opposing
data on the effects of AA on B lymphocytes that mediate humoral immunity.
However, AA enhances the proliferation of NK cells, a group of cytotoxic innate
lymphocytes. The influence of AA on natural killer (NK) cell function is less
clear. In summary, an increasing body of evidence indicates that AA positively
influences lymphocyte development and function. Since AA is a safe and cheap
nutritional supplement, it is worthwhile to further explore its potential
benefits for immune reconstitution of cancer patients treated with immunotoxic
drugs.
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