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10.1126/sciimmunol.aah6789 http://scihub22266oqcxt.onion/10.1126/sciimmunol.aah6789 C5111729!5111729 !27868108     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27868108 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27868108 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Immunol 2016 ; 1 (4 ): ä Nephropedia Template TP {{tp|p=27868108 |t=2016. Inflammatory monocytes hinder antiviral B cell responses |pdf=|usr=}}{{27868108 }} gab.com Text Inflammatory monocytes hinder antiviral B cell responses JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27868108 #FOAvip Antibodies are critical for protection against viral infections. However, several viruses, such as lymphocytic choriomeningitis virus (LCMV), avoid the induction of early protective antibody responses by poorly understood mechanisms. Here we analyzed the spatiotemporal dynamics of B cell activation to show that, upon subcutaneous infection, LCMV-specific B cells readily relocate to the interfollicular and T cell areas of the draining lymph node where they extensively interact with CD11b(+)Ly6C(hi) inflammatory monocytes. These myeloid cells were recruited to lymph nodes draining LCMV infection sites in a type I interferon-, CCR2-dependent fashion and they suppressed antiviral B cell responses by virtue of their ability to produce nitric oxide. Depletion of inflammatory monocytes, inhibition of their lymph node recruitment or impairment of their nitric oxide-producing ability enhanced LCMV-specific B cell survival and led to robust neutralizing antibody production. In conclusion, our results identify inflammatory monocytes as critical gatekeepers that prevent antiviral B cell responses and suggest that certain viruses take advantage of these cells to prolong their persistence within the host. Twit Text FOAVip Inflammatory monocytes hinder antiviral B cell responses ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27868108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27868108 #FOAvip English Wikipedia <ref>{{Cite pmid|27868108 }}</ref> Inflammatory monocytes hinder antiviral B cell responses #MMPMID27868108 Sammicheli S ; Kuka M ; Di Lucia P ; de Oya NJ ; De Giovanni M ; Fioravanti J ; Cristofani C ; Maganuco CG ; Fallet B ; Ganzer L ; Sironi L ; Mainetti M ; Ostuni R ; Larimore K ; Greenberg PD ; de la Torre JC ; Guidotti LG ; Iannacone M Sci Immunol 2016[Oct]; 1 (4 ): ä PMID27868108 show ga Antibodies are critical for protection against viral infections. However, several viruses, such as lymphocytic choriomeningitis virus (LCMV), avoid the induction of early protective antibody responses by poorly understood mechanisms. Here we analyzed the spatiotemporal dynamics of B cell activation to show that, upon subcutaneous infection, LCMV-specific B cells readily relocate to the interfollicular and T cell areas of the draining lymph node where they extensively interact with CD11b(+)Ly6C(hi) inflammatory monocytes. These myeloid cells were recruited to lymph nodes draining LCMV infection sites in a type I interferon-, CCR2-dependent fashion and they suppressed antiviral B cell responses by virtue of their ability to produce nitric oxide. Depletion of inflammatory monocytes, inhibition of their lymph node recruitment or impairment of their nitric oxide-producing ability enhanced LCMV-specific B cell survival and led to robust neutralizing antibody production. In conclusion, our results identify inflammatory monocytes as critical gatekeepers that prevent antiviral B cell responses and suggest that certain viruses take advantage of these cells to prolong their persistence within the host. äInflammatory monocytes hinder antiviral B cell responses (epmc).pdf DeepDyve Pubget Overpricing