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2014 ; 291
(1-2
): 32-40
Nephropedia Template TP
Cell Immunol
2014[Sep]; 291
(1-2
): 32-40
PMID25205002
show ga
Monocytes are blood-derived mononuclear phagocytic cells that traffic throughout
the body and can provide rapid innate immune effector responses in response to
microbial pathogen infections. Among blood monocytes, the most abundant subset in
mice is represented by inflammatory Ly6C(+) CCR2(+) monocytes and is the
functional equivalent of the CD14(+) monocytes in humans. Herein we focus on
published evidence describing the exquisite functional plasticity of these cells,
and we extend this overview to their multiples roles in vivo during host immune
defenses against microbial pathogen infections, as antigen-presenting cells,
inflammatory cells or Trojan horse cells.