Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25710773
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25710773
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 ASAIO+J
2015 ; 61
(4
): 463-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Inflammatory Response to Sorbent Hemodialysis
#MMPMID25710773
Rosales L
; Thijssen S
; Kruse A
; Sipahioglu MH
; Hirachan P
; Raimann JG
; Kuntsevich V
; Carter M
; Levin NW
; Kotanko P
ASAIO J
2015[Jul]; 61
(4
): 463-7
PMID25710773
show ga
Inflammation is common and associated with morbidity and mortality in
hemodialysis (HD) patients. Exposure to endotoxin contained in the dialysate may
trigger inflammation. Dialysate volume is substantially reduced in sorbent HD
compared with standard single-pass dialysis. In this prospective study
(Clinicaltrials.gov, number: NCT00788905), we compared the inflammatory response
to single-pass and sorbent HD. Patients receiving single-pass HD were studied
during 1 week of sorbent HD (Allient system; Renal Solutions, Warrendale, PA) and
1 week of single-pass HD. Patients were dialyzed using high-flux polysulfone
dialyzers. Midweek pre- and post-HD serum levels of high-sensitivity C-reactive
protein, interleukin (IL)-1?, IL-6, IL-10, interferon gamma, tumor necrosis
factor alpha (TNF-?), and eotaxin were determined and their intradialytic change
corrected for hemoconcentration during single-pass HD and sorbent HD compared by
paired t-test. We enrolled 18 patients, nine completed the study. Although TNF-?
decreased during both single-pass and sorbent HD (p < 0.001), none of the other
biomarkers changed significantly during HD. We observed no difference between
single-pass and sorbent HD. For the markers investigated in this study, there was
no difference in the acute intradialytic inflammatory response to single-pass or
sorbent HD.