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2017 ; 11
(ä): 316
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Inflammation: The Common Pathway of Stress-Related Diseases
#MMPMID28676747
Liu YZ
; Wang YX
; Jiang CL
Front Hum Neurosci
2017[]; 11
(ä): 316
PMID28676747
show ga
While modernization has dramatically increased lifespan, it has also witnessed
that the nature of stress has changed dramatically. Chronic stress result
failures of homeostasis thus lead to various diseases such as atherosclerosis,
non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90%
of human diseases is related to the activation of stress system, the common
pathways between stress exposure and pathophysiological processes underlying
disease is still debatable. Chronic inflammation is an essential component of
chronic diseases. Additionally, accumulating evidence suggested that excessive
inflammation plays critical roles in the pathophysiology of the stress-related
diseases, yet the basis for this connection is not fully understood. Here we
discuss the role of inflammation in stress-induced diseases and suggest a common
pathway for stress-related diseases that is based on chronic mild inflammation.
This framework highlights the fundamental impact of inflammation mechanisms and
provides a new perspective on the prevention and treatment of stress-related
diseases.