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2015 ; 12
(ä): 38-46
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Inflammasome control of viral infection
#MMPMID25771504
Lupfer C
; Malik A
; Kanneganti TD
Curr Opin Virol
2015[Jun]; 12
(ä): 38-46
PMID25771504
show ga
The inflammasome is a caspase-1 containing complex that activates the
proinflammatory cytokines IL-1? and IL-18 and results in the proinflammatory cell
death known as pyroptosis. Numerous recent publications have highlighted the
importance of inflammasome activation in the control of virus infection.
Inflammasome activation during viral infection is dependent on a variety of
upstream receptors including the NOD-like receptor, RIG-I-like receptor and
AIM2-like receptor families. Various receptors also function in inflammasome
activation in different cellular compartments, including the cytoplasm and the
nucleus. The effectiveness of inflammasomes at suppressing virus replication is
highlighted by the prevalence and diversity of virus encoded inflammasome
inhibitors. Also, the host has a myriad of regulatory mechanisms in place to
prevent unwanted inflammasome activation and overt inflammation. Finally, recent
reports begin to suggest that inflammasome activation and inflammasome modulation
may have important clinical applications. Herein, we highlight recent advances
and discuss potential future directions toward understanding the role of
inflammasomes during virus infection.
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