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10.1016/j.celrep.2017.10.027 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.10.027 C5687836!5687836 !29091757     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29091757 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29091757 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2017 ; 21 (5 ): 1169-1179 Nephropedia Template TP {{tp|p=29091757 |t=2017. Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses |pdf=|usr=}}{{29091757 }} gab.com Text Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29091757 #FOAvip Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of sialylated glycans, which are thought to serve as receptors for the infectious entry of wild-type JCV. In this report, we show that non-sialylated glycosaminoglycans (GAGs) can serve as alternative attachment receptors for the infectious entry of both wild-type and PML mutant JCV strains. After GAG-mediated attachment, PML mutant strains engage non-sialylated non-GAG co-receptor glycans, such as asialo-GM1. JCV-neutralizing monoclonal antibodies isolated from patients who recovered from PML appear to block infection by preventing the docking of post-attachment co-receptor glycans in an apical pocket of the JCV major capsid protein. Identification of the GAG-dependent/sialylated glycan-independent alternative entry pathway should facilitate the development of infection inhibitors, including recombinant neutralizing antibodies. Twit Text FOAVip Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29091757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29091757 #FOAvip English Wikipedia <ref>{{Cite pmid|29091757 }}</ref> Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses #MMPMID29091757 Geoghegan EM ; Pastrana DV ; Schowalter RM ; Ray U ; Gao W ; Ho M ; Pauly GT ; Sigano DM ; Kaynor C ; Cahir-McFarland E ; Combaluzier B ; Grimm J ; Buck CB Cell Rep 2017[Oct]; 21 (5 ): 1169-1179 PMID29091757 show ga Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of sialylated glycans, which are thought to serve as receptors for the infectious entry of wild-type JCV. In this report, we show that non-sialylated glycosaminoglycans (GAGs) can serve as alternative attachment receptors for the infectious entry of both wild-type and PML mutant JCV strains. After GAG-mediated attachment, PML mutant strains engage non-sialylated non-GAG co-receptor glycans, such as asialo-GM1. JCV-neutralizing monoclonal antibodies isolated from patients who recovered from PML appear to block infection by preventing the docking of post-attachment co-receptor glycans in an apical pocket of the JCV major capsid protein. Identification of the GAG-dependent/sialylated glycan-independent alternative entry pathway should facilitate the development of infection inhibitors, including recombinant neutralizing antibodies. |*Virus Internalization/drug effects [MESH] |Antibodies, Monoclonal/*immunology [MESH] |Antibodies, Neutralizing/*immunology/pharmacology [MESH] |Capsid Proteins/genetics/immunology/metabolism [MESH] |Cell Line, Tumor [MESH] |Gangliosides/pharmacology [MESH] |Genotype [MESH] |Glycosaminoglycans/metabolism [MESH] |Hemagglutination/drug effects [MESH] |Humans [MESH] |JC Virus/genetics/immunology/*physiology [MESH] |Leukoencephalopathy, Progressive Multifocal/metabolism/pathology/virology [MESH] |Mutation [MESH] |Neuraminidase/metabolism [MESH] |Nucleotide Transport Proteins/antagonists & inhibitors/genetics/metabolism [MESH] |Protein Binding [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH]Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses (epmc).pdf DeepDyve Pubget Overpricing